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STEMCELL Technologies Anacardic Acid

Epigenetic modifier; Inhibits histone acetyltransferase (HAT)

Brand: STEMCELL Technologies 73194

Product Code. 17180182

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Description

Anacardic Acid is a 6-alkyl salicyclic acid that inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (pCAF; IC₅₀ values of 8.5 and 5 μM, respectively; Balasubramanyam et al.) Anacardic Acid inhibits HAT-dependent transcription and protein SUMOylation (Cui et al.; Fukuda et al.) In addition, Anacardic Acid is an activator of Aurora kinase A-mediated phosphorylation of Histone H3 (Kishore et al.) At higher concentrations (25 μM), Anacardic Acid suppresses NF-κB activation and inhibits IκB-α phosphorylation (Sung et al.)

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