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beta Arrestin 1 Monoclonal Antibody (ZA005), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen 395000
This item is not returnable.
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Description
Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of Gprotein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
Specifications
| beta Arrestin 1 | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 0.1% sodium azide; pH 7.4 | |
| P29066, P49407, Q8BWG8 | |
| ARRB1 | |
| Synthetic peptide derived from the C-terminal region of human beta-arrestin 1 | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG1 κ |
| ELISA, Immunocytochemistry, Western Blot | |
| ZA005 | |
| Unconjugated | |
| ARRB1 | |
| 1200006I17Rik; ARB1; ARR1; ARRB1; ARRB1 protein; arrdc1; arrestin; arrestin 2; arrestin beta 1; arrestin beta-1; arrestin, beta 1; arrestin-2; AW208571; BARRES; beta-arrestin; beta-arrestin1; beta-arrestin-1; G430100A01Rik; Non-visual arrestin-2 | |
| Mouse | |
| Protein A | |
| RUO | |
| 109689, 25387, 408 | |
| -20°C | |
| Liquid |