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Invitrogen™ CDK4 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA527827
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Beskrivning
Recommended positive controls: 293T, A431, HeLa, HepG2, NIH-3T3, PC-12. Predicted reactivity: Mouse (95%), Rat (94%), Pig (98%), Sheep (96%), Rhesus Monkey (100%), Bovine (96%).
CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.
Specifikationer
| CDK4 | |
| Polyclonal | |
| Unconjugated | |
| Cdk4 | |
| Cdk4; Cell division protein kinase 4; CMM3; Crk3; cyclin dependent kinase 4; cyclin-dependent kinase 4; MGC14458; p34>PSK-J3>/cdk4; PSK-J3; serine/threonine kinase; Unknown (protein for MGC:133903) | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 1019, 12567, 510618, 94201 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
| 0.82 mg/mL | |
| PBS with 20% glycerol and 0.025% ProClin 300; pH 7 | |
| P11802, P30285, P35426, Q32KY4 | |
| Cdk4 | |
| Recombinant protein encompassing a sequence within the center region of human CDK4. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Bovine, Human, Mouse, Rat | |
| Antibody | |
| IgG |
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