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Invitrogen™ DR4 Monoclonal Antibody (DR-4-02), FITC
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA119757
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Beskrivning
This antibody recognizes an extracellular epitope of TRAIL-R1 (DR4), a human death receptor 4 expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumor-derived cell lines.
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
Specifikationer
| DR4 | |
| Monoclonal | |
| 0.1 mg/mL | |
| PBS with 0.2% BSA and 15mM sodium azide; pH 7.4 | |
| O00220 | |
| TNFRSF10A | |
| Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Flow Cytometry | |
| DR-4-02 | |
| FITC | |
| TNFRSF10A | |
| APO2; CD261; cytotoxic TRAIL receptor; death receptor 4; DR4; MGC9365; sCD261; soluble CD261; soluble TRAIL; sTRAIL; TNF receptor superfamily member 10a; TNF-related apoptosis-inducing ligand receptor 1; TNFRSF10A; TRAIL R1; TRAIL receptor 1; TRAILR1; TRAIL-R1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a | |
| Mouse | |
| Size-exclusion chromatography | |
| RUO | |
| 8797 | |
| 4°C, store in dark, DO NOT FREEZE! | |
| Liquid |
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