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Invitrogen™ IRAK1 Monoclonal Antibody (8F1A7)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA515783
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Beskrivning
A suggested positive control is IRAK recombinant protein.
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK's association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.
Specifikationer
| IRAK1 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 0.02% sodium azide | |
| P51617, Q62406 | |
| Irak1 | |
| Recombinant protein corresponding to amino acids 618 - 712 of human IRAK. | |
| 100 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG1 |
| Immunohistochemistry, Western Blot | |
| 8F1A7 | |
| Unconjugated | |
| Irak1 | |
| AA408924; Il1rak; interleukin 1 receptor associated kinase 1; interleukin-1 receptor-associated kinase 1; interleukin-1 receptor-associated kinase-1; IRAK; Irak1; IRAK-1; IRAK1-S; mPLK; pelle; Pelle homolog; pelle-like protein kinase; Plpk; RGD1563841 | |
| Mouse | |
| Protein G | |
| RUO | |
| 16179, 363520, 3654 | |
| -20°C | |
| Liquid |
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