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IRAK1 Monoclonal Antibody (8F1A7), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA515783

Product Code. 12807812

  • 4605.00 SEK / 100µg

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Description

Description

A suggested positive control is IRAK recombinant protein.

IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK's association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

IRAK1
Monoclonal
1 mg/mL
PBS with 0.02% sodium azide
P51617, Q62406
Irak1
Recombinant protein corresponding to amino acids 618 - 712 of human IRAK.
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG1
Immunohistochemistry, Western Blot
8F1A7
Unconjugated
Irak1
AA408924; Il1rak; interleukin 1 receptor associated kinase 1; interleukin-1 receptor-associated kinase 1; interleukin-1 receptor-associated kinase-1; IRAK; Irak1; IRAK-1; IRAK1-S; mPLK; pelle; Pelle homolog; pelle-like protein kinase; Plpk; RGD1563841
Mouse
Protein G
RUO
16179, 363520, 3654
-20°C
Liquid
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