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Invitrogen™ NOX1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA588280
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Beskrivning
Immunogen sequence: WYKFQCADHN LKTKKIYFYW ICRETGAFSW FNNLLTSLEQ EMEELGKVGF LNYRLFLTGW DSNIVGHAAL NFDKATDIVT GLKQKTSFGR PMWDNEFSTI ATSHPKSVVG VFLCGPRTLA KSLRKCCHRY SSLDPRKVQF YFNKENF Positive Samples: Rat liver; Cellular Location: Cell projection, Multi-pass membrane protein, invadopodium membrane.
Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Three splice variants of NOX1 have been identified, NOH-1L, NOH-1S and NOH-1Lv. NOH-1S is a voltage-gated proton channel that participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H (+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. NOX1 have the potential to be effective treatments for a range of ischemic diseases.
Specifikationer
| NOX1 | |
| Polyclonal | |
| Unconjugated | |
| Nox1 | |
| GP91 phox homolog; GP91-2; mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating); mitogenic oxidase 1; MOX1; MOX-1; NADH/NADPH mitogenic oxidase subunit P65-MOX; NADPH oxidase 1; NADPH oxidase 1 alpha; NADPH oxidase homolog-1; NOH1; NOH-1; Nox1; NOX-1; NOX1a; NOX1alpha | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 237038, 27035 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Immunohistochemistry (Paraffin), Western Blot | |
| 0.98 mg/mL | |
| PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3 | |
| Q8CIZ9, Q9Y5S8 | |
| Nox1 | |
| A synthetic peptide corresponding to a sequence within amino acids 418-564 of human NOX1 (NP_0089832?). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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