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Invitrogen™ Human PDGFRB (PDGFR beta), His Tag Recombinant Protein

Produktkod. p-7181622
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Kvantitet:
1 mg
10 μg
Förpackningsstorlek:
10µg
1mg
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For Research Use Only. All usage must comply with product instructions.

Produktkod. 11589286

Brand: Invitrogen™ P3082

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For Research Use Only. All usage must comply with product instructions.

Beskrivning

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Recombinant, Catalytic Domain, Cytoplasmic.

PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
TRUSTED_SUSTAINABILITY

Specifikationer

Tillträdesnummer P09619
Koncentration See Label
För användning med (applikation) Kinase Assay
Formulering 20mM tris with 1mM DTT, 50% glycerol, 0.05% NP-40, 100mM NaCl, 0.05mM EDTA and no preservative; pH 7.5
Gen-ID (Entrez) 5159
Molekylvikt (g/mol) 66.3 kDa
Namn Human PDGFRB (PDGFR beta), His Tag
pH-intervall 7.5
Reningsmetod Purified
Kvantitet 10 μg
Förvaringskrav -80°C, Avoid Freeze/Thaw Cycles
Regulatorisk status RUO
Gene Alias AI528809; Beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140B; CD140b antigen; IBGC4; IMF1; JTK12; KOGS; PDGF beta chain; PDGF Receptor beta; Pdgfr; Pdgfr1; PDGFR-1; PDGFRB; PDGF-R-beta; PDGFR-beta; PENTT; platelet derived growth factor receptor beta; platelet derived growth factor receptor, beta polypeptide; platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; Platelet-derived growth factor receptor, beta; platelet-derived growth factor receptor, beta polypeptide
Vanligt namn PDGFRB (CD140b)
Gensymbol Pdgfrb
KinaseFamily PDGFR Kinase Family
Protein Längd 558-1106
Produkttyp Protein
Konjugera Unconjugated
Art Human
Rekombinant Recombinant
Protein Tag His-tag
Sekvens 558-1106
Innehåll och lagring -80°C, Avoid Freeze/Thaw Cycles
Analysinträde Biochemical phospho-specific activity (no antibody), Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group Tyrosine Kinases
Frakt skick Dry Ice
Systemkompatibilitet LanthaScreen™ Antibody, LanthaScreen™ Substrate, Z'-LYTE™, Omnia™ Bulk Substrate
Målinträde PDGFRB
Target Gene platelet-derived growth factor receptor, beta polypeptide
Uttryckssystem Baculovirus
Proteinfamilj Kinases & Inhibitors
Proteinform Recombinant, Catalytic Domain, Cytoplasmic
Form Liquid
Protein subtyp Receptor Tyrosine Kinases
Forskningskategori Signal Transduction
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