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Ro 31-8220 mesylate, Tocris Bioscience™

Product Code. 30001343
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Quantity:
10 mg
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This item is not returnable. View return policy

Description

Protein kinase inhibitor

Protein kinase C inhibitor, with activity at other protein kinases (IC50 values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na+ channels in the micromolar range. Induces protein-protein interaction between mutant SMAD4R361H and SMAD3, leading to reactivation of dormant SMAD4R361H-mediated transcriptional activity and restoration of TGF-β-induced tumor suppression activity in SMAD4 mutant cancer cells.

Specifications

CAS 138489-18-6
Molecular Formula C26H27N5O5S2
Quantity 10 mg
Synonym ro 31-8220 mesylate, bisindolylmaleimide ix, methanesulfonate, insolution ro-31-8220, 3-1-3-amidinothio propyl-1h-indol-3-yl-3-1-methyl-1h-indol-3-yl maleimide, bisindoylmaleimidine ix, bmk1-d9, bisindolylmaleimide ix mesylate, ro?31-8220?methanesulfonate
InChI Key SAWVGDJBSPLRRB-UHFFFAOYSA-N
SMILES CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O
IUPAC Name methanesulfonic acid;3-[3-[4-(1-methylindol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]propyl carbamimidothioate
Molecular Weight (g/mol) 553.652
PubChem CID 11628205
Formula Weight 553.65
Percent Purity >97%
Chemical Name or Material Ro 31-8220 mesylate
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