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STEMCELL Technologies AKT Inhibitor VIII

PI3K/AKT pathway inhibitor; Inhibits AKT1, AKT2, and AKT3

2600.10 SEK - 4534.65 SEK

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Product Code	Brand	Quantity	Price	Quantity & Availability
Product Code	Brand	Quantity	Price	Quantity & Availability
17110152 View Documents missing translation for 'viewProductCertificates'	STEMCELL Technologies 72942	1 mg	2600.10 SEK 1mg View alternative products Save Up to »		Please sign in to purchase this item. Need a web account? Register with us today!

17120152 View Documents missing translation for 'viewProductCertificates'	STEMCELL Technologies 72944	10 mg	4534.65 SEK 10mg View alternative products Save Up to »		Please sign in to purchase this item. Need a web account? Register with us today!

Description

AKT Inhibitor VIII is a cell-permeable, allosteric inhibitor of all three forms of the kinase AKT (AKT1, AKT2, and AKT3) with IC₅₀ values of 58, 210, and 2,200 nM, respectively (Lindsley et al.; Calleja et al.) It displays good selectivity against a panel of 70 other kinases with micromolar inhibition against some kinases, such as calcium/calmodulin-dependent protein kinase 1 and smooth muscle myosin light-chain kinase (Logie et al.)
Sensitizes prostate tumor and cervical carcinoma cells to apoptotic stimuli (DeFeo-Jones et al.)
Blocks mitosis and inhibits migration of HeLa cells (Jo et al.)
Reduces insulin-dependent gene repression in liver cells leading to reduced insulin sensitivity (Logie et al.)

Specifications

Description