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STEMCELL Technologies AKT Inhibitor X (Hydrochloride)
PI3K/AKT pathway inhibitor; Inhibits AKT
Brand: STEMCELL Technologies 72952
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Description
- AKT Inhibitor X is a cell-permeable phenoxazine-derivative inhibitor of AKT kinase phosphorylation with an IC50 of ∼1 - 2 μM
- AKT Inhibitor X blocks translocation of AKT after insulin-like growth factor 1 (IGF-1) treatment (Thimmaiah et al.) This product is supplied as the hydrochloride salt of the molecule
- Inhibits growth and induces apoptosis of human rhabdomyosarcoma cell lines (Thimmaiah et al.)
- Inhibits proliferation of breast cancer cell lines, alone or synergistically with chloroquine (Hu et al.)
- Reduces replication of Myxoma virus in a variety of human tumor cell lines (Werden & McFadden)
- Induces autophagy in neurons and is neuroprotective in a primary neuronal Huntington Disease cellular model (Tsvetkov et al.)
Specifications
| 925681-41-0 | |
| 10 mg | |
| ≥95% |
| 10-DEBC hydrochloride | |
| C20H25ClN2O · HCl |