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Thermo Scientific Chemicals Aldosterone, 98%

Aldosterone, CAS # 52-39-1, is a hormone secreted by the adrenal cortex, which regulates electrolyte and water balance by increasing the renal retention of sodium and potassium excretion.

1443.72 SEK - 13241.98 SEK

Chemical Identifiers

CAS 52-39-1
Molecular Formula C21H28O5
Molecular Weight (g/mol) 360.45
MDL Number MFCD00051136
InChI Key PQSUYGKTWSAVDQ-ZVIOFETBSA-N
Synonym aldosterone, electrocortin, aldocortin, aldocorten, aldocortene, +-aldosterone, elektrocortin, d-aldosterone, reichstein x, 18-oxocorticosterone
PubChem CID 5839
ChEBI CHEBI:27584
IUPAC Name (8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
SMILES CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C=O)O
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Thermo Scientific Chemicals
215360050
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Description

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description
Aldosterone is a pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland by the action of aldosterone synthase (CYP11B2)
It modulates electrolyte and water balance by increasing the renal retention of sodium and potassium excretion.
Applications
Aldosterone binds to mineralocorticoid receptors (MR; NR3C2) and MR-aldosterone complexes regulating the expression of genes involved in the retention of sodium, secretion of potassium, and water reabsorption, resulting in an increase in the blood pressure
In vitro, it has been involved with the pathogenesis of obesity-related glomerulopathy through activation of Wnt/β-catenin signaling in podocytes
Aldosterone has been used in combination with salt to induce renal injury in mice
It is used to stimulate primary liver sinusoidal endothelial cells
Specifications

Chemical Identifiers

52-39-1
360.45
PQSUYGKTWSAVDQ-ZVIOFETBSA-N
5839
(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
C21H28O5
MFCD00051136
aldosterone, electrocortin, aldocortin, aldocorten, aldocortene, +-aldosterone, elektrocortin, d-aldosterone, reichstein x, 18-oxocorticosterone
CHEBI:27584
CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C=O)O

Specifications

52-39-1
100.0
6.0% max. (105°C, 3 hrs)
98%
MFCD00051136
15, 218
aldosterone, electrocortin, aldocortin, aldocorten, aldocortene, +-aldosterone, elektrocortin, d-aldosterone, reichstein x, 18-oxocorticosterone
CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C=O)O
360.45
CHEBI:27584
≥97.5% (HPLC)
Aldosterone, 98%
97.5
White
Authentic
C21H28O5
08, IV, 3491
+150° to +162° (20°C, 589nm) (c=0.1, CHCl3)
PQSUYGKTWSAVDQ-ZVIOFETBSA-N
(8S,9S,10R,11S,13R,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthrene-13-carbaldehyde
5839
360.45
Crystalline Powder
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missing translation for 'einecsNumber' : 200-139-9

missing translation for 'rtecsNumber' : TU4523000

missing translation for 'tsca' : TSCA

Product Identifier
  • Aldosterone

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