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Eurofins DiscoverX Alk Protein, Active
Active, N-terminal His6-tagged, recombinant human ALK, residues 1058-end, for use in Kinase Assays.
Brand: Eurofins DiscoverX 14-555
Additional Details : Weight : 4.70710kg
Description
ALK or anaplastic lymphoma kinase (Ki-1) is a membrane-spanning tyrosine kinase receptor that is most closely related to leukocyte tyrosine kinase. No function has been ascribed for ALK; however, its restricted expression in neural tissue suggests that this receptor might play an important role in the normal development and function of the nervous system. Large-cell anaplastic lymphoma is a subtype of non-Hodgkin's lymphoma. Over half of these lymphomas have a chromosomal translocation t(2;5), that leads to the expression of a hybrid protein comprised of the nucleolar phosphoprotein nucleophosmin (NPM) and ALK.
GenBank U62540
Specifications
| mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. | |
| 10 μg | |
| Recombinant | |
| Recombinant enzyme expressed in Sf21 insect cells | |
| ≥50% |
| 63.8 kDa | |
| Human | |
| N-terminal 6His | |
| Truncated | |
| Alk, active |