BD Biosciences™ Anti-Human CD4 FITC/CD38 PE/CD3 PerCP/HLA-DR APC with BD Trucount™ Tubes (RUO/GMP)

Description

• Clone SK3 (also known as Leu3a) G46-6 HB7 SK7 (also known as Leu-4) (RUO (GMP))
• CD4, clone SK3, is derived from hybridization of mouse NS-1 myeloma cells with spleen cells from BALB/c mice immunized with human peripheral blood T lymphocytes.
• CD38, clone HB7, is derived from hybridization of mouse P3-X63-Ag8.653 myeloma cells with spleen cells from BALB/c mice immunized with the BJAB cell line.
• CD3, clone SK7, is derived from hybridization of mouse NS-1 myeloma cells with spleen cells from BALB/c mice immunized with human thymocytes.
• Anti–HLA-DR, clone L243, is derived from the hybridization of mouse NS-1/1-Ag4 myeloma cells with spleen cells from BALB/c mice immunized with the human lymphoblastoid B-cell line RPMI 8866.
• CD4 recognizes an antigen that interacts with class II molecules of the major histocompatibility complex (MHC) and is the primary receptor for the human immunodeficiency virus. The cytoplasmic portion of the antigen is associated with the protein tyrosine kinase p56^lck.The CD4 antigen can regulate the function of the CD3 antigen/Tcell antigen receptor (TCR) complex. CD4 also reacts with monocytes/macrophages that have an antigen density lower than that on helper/inducer T lymphocytes.
• CD38 recognizes an integral membrane glycoprotein, Mr 45 kDalton (kDa), with a protein core of 35 kDa.
• CD3 recognizes the epsilon chain of the CD3 antigen/TCR complex. This complex is composed of at least six proteins that range in molecular weight from 20 to 30 kDa. The antigen recognized by the CD3 antibody is noncovalently associated with either α/β or γ/δ TCR (70 to 90 kDa).
• Anti–HLA-DR recognizes a human class II MHC antigen. The antigen is a transmembrane glycoprotein composed of α and β subunits that have molecular weights of 36 and 27 kDa, respectively. Anti–HLA-DR reacts with a nonpolymorphic HLA-DR epitope and does not cross-react with HLA-DQ or HLA-DP molecules.
• Contents:
• Specificity: CD4, Clone: SK3 (also known as Leu3a), Format: FITC, Isotype: IgG₁K, Entrez Gen ID: 920
• Specificity: HLA-DR, Clone: G46-6, Format: APC, Isotype: IgG_2aK
• Specificity: CD38, Clone: HB7, Format: PE, Isotype: IgG₁K
• Specificity: CD3, Clone: SK7 (also known as Leu-4), Format: PerCP, Isotype: IgG₁K, Entrez Gen ID: 916
• Research applications include studies of the following:
  • Activated T-helper cells in AIDS
  • Activate T lymphocytes