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NF-κB p65 Mouse, Unlabeled, Clone: 20, BD
Mouse Monoclonal Antibody
Brand: BD Biosciences 610868
2411.78 SEK valid until 2025-12-31
Use promo code "25339" to get your promotional price.
This item is not returnable.
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Description
NF-κB is a ubiquitously expressed transcription factor that regulates many cytokine and Ig genes. It is involved in immune, inflammatory, viral, and acute phase responses. The most studied NF-κB complex consists of the p50 and p65 subunits, both containing a 300 amino acid region with homology to the Rel proto-oncogene product. The p50 subunit binds DNA, whereas the p65 subunit is responsible for the interaction of NF-κB with its inhibitor, IκB. In most cell types, the p50/p65 heterodimer is located within the cytoplasm complexed to IκB. This complex prevents nuclear translocation and activity of NF-κB. In response to stimuli such as cytokines, LPS, and viral infections, IκB is phosphorylated at critical residues. This phosphorylation induces dissociation of the IκB/NF-κB complex, allowing the free heterodimeric
NF-κB to form a heterotetramer that translocates to the nucleus. In the nucleus, it binds to the κB site within promoters and enhancers and functions as a transcriptional activator.
Immunofluorescence, Western Blotting
Specifications
| NF-κB p65 | |
| Monoclonal | |
| 250μg/mL | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Human NF-κB aa. 136-224 | |
| 50 μg | |
| Cell Biology | |
| Canine, Frog, Human, Rabbit, Rat | |
| IgG1 |
| Western Blot | |
| 20 | |
| Unconjugated | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at -20°C. |
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Product Title
NF-κB p65 Mouse, Unlabeled, Clone: 20, BD > 50μg; Unlabeled
For Research Use Only.
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