Rb Mouse anti-Human, Mouse, Rat, Clone: 1F8, Invitrogen™

Description

MA1-34070 detects RB1 from mouse, rat, and human samples. MA1-34070 has been successfully used in immunoprecipitation, immunohistochemistry (paraffin tissue), and Western blot applications. A suggested positive control is K562 WCL. The MA1-34070 immunogen is recombit full length protein (Human).

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.