TYRO3 Monoclonal Antibody (1C10E8, 9A3F2), Invitrogen™

Description

MA5-15340 targets TYRO3 in indirect ELISA, ICC, IF and WB applications and shows reactivity with Human samples. The MA5-15340 immunogen is purified recombinant fragment of TYRO3 expressed in E. Coli.

TYRO3 (tyrosine-protein kinase receptor TYRO3) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. It regulates many physiological processes including cell survival, migration, and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by a ligand, TYRO3 plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation, signal transduction, cell adhesion. and cytoskeleton reorganization.