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Aquaporin 2 Monoclonal Antibody (7H8B5), Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen MA531630
This item is not returnable.
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Description
Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans. A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells. Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking.
Specifications
| Aquaporin 2 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 0.05% sodium azide | |
| P41181 | |
| AQP2 | |
| Purified recombit fragment of human AQP2 (AA: 149-271) expressed in E. coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| ELISA, Western Blot | |
| 7H8B5 | |
| Unconjugated | |
| AQP2 | |
| AQP-CD; WCH-CD | |
| Mouse | |
| Protein G | |
| RUO | |
| 359 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |