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  6. Bestatin, Thermo Scientific Chemicals

Bestatin, Thermo Scientific Chemicals

Product Code. 15463759
100 mg
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Quantity:
100 mg
250 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Bestatin can indirectly act on monocytes by inhibiting Aminopeptidase B, which in turn inhibits the catabolism of tuftsin. Bestatin has also been shown to inhibit Leukotriene A4 hydrolase. It can directly stimulate lymphocytes through its fixation on the cell surface. The agent has been used in multiple leukemia studies. Bestatin is an aminopeptidase inhibitor, inhibits enkephalin metabolism and leukotriene A4 hydrolase. Inhibits tumor cell proliferation.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Bestatin can indirectly act on monocytes by inhibiting Aminopeptidase B, which in turn inhibits the catabolism of tuftsin. Bestatin has also been shown to inhibit Leukotriene A4 hydrolase. It can directly stimulate lymphocytes through its fixation on the cell surface. The agent has been used in multiple leukemia studies. Bestatin is an aminopeptidase inhibitor, inhibits enkephalin metabolism and leukotriene A4 hydrolase. Inhibits tumor cell proliferation.

Solubility
Soluble in water (<1 25), DMSO (2 mg/ml), methanol (5 mg/ml), 1eq. NaOH (50 mM), ethanol (<1mg/mL at 25°C), acetic acid, aq. HCl, and alkaline solution. Insoluble in ethyl acetate, benzene, hexane, and chloroform.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 58970-76-6
Molecular Formula C16H24N2O4
Molecular Weight (g/mol) 308.38
MDL Number MFCD00083262
InChI Key VGGGPCQERPFHOB-MCIONIFRSA-N
Synonym bestatin, ubenimex, ubenimexum latin, ubenimex inn:jan, bestatin;ubenimex, s-2-2s,3r-3-amino-2-hydroxy-4-phenylbutanamido-4-methylpentanoic acid, ubenimex bestatin, chembl29292, 2s,3r-3-amino-2-hydroxy-4-phenylbutanoyl-l-leucine, 3-r-amino-2-s-hydroxy-4-phenylbutanoyl-s-leucine
PubChem CID 72172
IUPAC Name (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid
SMILES CC(C)C[C@@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(O)=O

Specifications

Melting Point 233°C to 236°C
Color White
Quantity 100 mg
Merck Index 14,9842
Solubility Information Soluble in water (<1 25),DMSO (2mg/ml),methanol (5mg/ml),1eq. NaOH (50 mM),ethanol (<1mg/ml at 25°C),acetic acid,aq. HCl,and alkaline solution. Insoluble in ethyl acetate,benzene,hexane,and chloroform.
Formula Weight 308.37
Physical Form Powder
Chemical Name or Material Bestatin

Safety and Handling

compliance-icons
Product Identifier
  • Bestatin
 Signal Word
  • Warning
 Hazard Category
  • Serious eye damage/eye irritation Category 2
  • Skin corrosion/irritation Category 2
  • Specific target organ toxicity Category 3
 Hazard Statement
  • H315-Causes skin irritation.
  • H319-Causes serious eye irritation.
  • H335-May cause respiratory irritation.
 Precautionary Statement
  • P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
 Supplemental information
  • MIXTURE LIST-Contains : [S-(R*,S*)]-N-(3-Amino-2-hydroxy-4-phenyl butyroyl)-L-leucine
SDS

RUO – Research Use Only

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