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CARD8 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA560397
This item is not returnable.
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Description
Immunogen sequence: PITSNTLIYY HPHPEDIKFH LYLVPSDALL TKAIDDEEDR FHGVRLQTSP PMEPLNFGSS YIVSNSANLK VMPKELKLSY RSPGEIQHFS KFYAGQMK Highest antigen sequence identity to the following orthologs: Mouse - 57%, Rat - 55%.
Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD8. This protein interacts with DRAL, a p53-responsive protein implicated in the induction of apoptosis, and caspase-1 and its related proteins ICEBERG and pesudo-ICE. Although there are conflicting reports on whether CARD8 acts a pro- or anti-apoptotic protein, it has been suggested that it functions as an adaptor molecule regulating caspase-1 and NF-kappa-B activation.Specifications
CARD8 | |
Polyclonal | |
Unconjugated | |
CARD8 | |
Apoptotic protein NDPP1; CARD 8; CARD inhibitor of NF-kappaB-activating ligands; CARD8; CARDINAL; CARD-inhibitor of NF-kappa-B-activating ligand; caspase recruitment domain family member 8; caspase recruitment domain family, member 8; caspase recruitment domain-containing protein 8; DACAR; DAKAR; DKFZp779L0366; KI; KIAA0955; NDPP; NDPP1; TUCAN; Tumor up-regulated CARD-containing antagonist of CASP9; tumor up-regulated CARD-containing antagonist of caspase nine | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
22900 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry, Immunohistochemistry | |
0.1 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q9Y2G2 | |
CARD8 | |
Recombinant protein corresponding to Human CARD8 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only