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STEMCELL Technologies CAY10512
NF-κB pathway inhibitor; Inhibits NF-κB
Brand: STEMCELL Technologies 73022
Additional Details : Weight : 0.05000kg
Description
- CAY10512 is an analog of Resveratrol that is 100-fold more potent (IC50 = 150 nM) at inhibiting NF-κB activation by TNF-α (Heynekamp et al.) Unlike Resveratrol and some other trans-stilbene analogs, CAY10512 does not exhibit antioxidant activity (up to 15 μM) in either the ferric reducing/antioxidant power (FRAP) or total radical antioxidant parameter (TRAP) assays (Heynekamp et al.) Like Resveratrol, CAY10512 also inhibits lipopolysaccharide-induced expression of COX-2 (Heynekamp et al.)
- Protects human islets from instant blood-mediated inflammatory response leading to improved survival of transplanted islets in in vitro tube model (Kanak et al.)
- Inhibits induction of NF-κB and subsequent upregulation of inflammatory microRNAs in Alzheimer disease model of human neuronal-glial cells in vitro (Lukiw)
Specifications
139141-12-1 | |
100 mg | |
C15H13FO | |
≥97% |