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STEMCELL Technologies CAY10512

NF-κB pathway inhibitor; Inhibits NF-κB

Brand: STEMCELL Technologies 73022

Additional Details : Weight : 0.05000kg

Product Code. 17140162

Estimated Shipment: 20-09-2024
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Description

CAY10512 is an analog of Resveratrol that is 100-fold more potent (IC₅₀ = 150 nM) at inhibiting NF-κB activation by TNF-α (Heynekamp et al.) Unlike Resveratrol and some other trans-stilbene analogs, CAY10512 does not exhibit antioxidant activity (up to 15 μM) in either the ferric reducing/antioxidant power (FRAP) or total radical antioxidant parameter (TRAP) assays (Heynekamp et al.) Like Resveratrol, CAY10512 also inhibits lipopolysaccharide-induced expression of COX-2 (Heynekamp et al.)
Protects human islets from instant blood-mediated inflammatory response leading to improved survival of transplanted islets in in vitro tube model (Kanak et al.)
Inhibits induction of NF-κB and subsequent upregulation of inflammatory microRNAs in Alzheimer disease model of human neuronal-glial cells in vitro (Lukiw)

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