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Eurofins DiscoverX Cdk2/Cyclin E Protein, Active
Active complex of recombinant full length human Cdk2 containing a C-terminal His6-tag, and recombinant full-length human Cyclin E containing an N-terminal GST-tag, for use in Kinase Assays.
Brand: Eurofins DiscoverX 14-475M
This item is not returnable.
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Description
The cyclin-dependent kinases (CDKs), are a family of serine threonine protein kinases, that control the cell division cycle. In mammals, nine different CDKs (cdk 1 to cdk 9) have been identified. CDKs are regulated on various levels including binding of proteins (cyclins, inhibitors, and assembly factors), protein degradation, transcriptional control, localization, and multiple phosphorylations. This leads to timely regulation of CDK activity, allowing progression from one cell cycle phase to the next. The cdk2 promotes the G1/S trasition and progression through the S phase when bound to specific cyclins (E and A). Recent evidences indicate that CDK2 is involved in cell cycle independent functions such as DNA damage repair.
EMBL M68520 / GenBank NM_001238
Specifications
| mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol, 270 mM sucrose. Frozen solution. | |
| 250 μg | |
| Recombinant | |
| Recombinant enzyme expressed in Sf21 Insect cells | |
| Combined ≥51% |
| 34 kDa (CDK2) and 74 kDa (Cyclin E1) | |
| Human | |
| C-terminal 6His / N-terminal GST | |
| Full-length | |
| CDK2/Cyclin E, active |