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Chloromethyl methyl sulfide, 94%, Thermo Scientific Chemicals
Description
Chloromethyl methyl sulfide is used as a methylene transfer reagent for iron(II) mediated cyclopropanation and for carbonyl and aromatic compounds. It protects alcohols as their methylthiomethyl (MTM) ethers by reaction, e.g. with NaH/NaI in DME. It is also used for the preparation of MTM esters of carboxylic acids, e.g. by treatment of the K salt of the acid in the presence of NaI and 18-crown-6 and for reaction with cyclopentadienyl iron dicarbonyl dimer in the formation of an iron-containing methylene transfer agent.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Chloromethyl methyl sulfide is used as a methylene transfer reagent for iron(II) mediated cyclopropanation and for carbonyl and aromatic compounds. It protects alcohols as their methylthiomethyl (MTM) ethers by reaction, e.g. with NaH/NaI in DME. It is also used for the preparation of MTM esters of carboxylic acids, e.g. by treatment of the K salt of the acid in the presence of NaI and 18-crown-6 and for reaction with cyclopentadienyl iron dicarbonyl dimer in the formation of an iron-containing methylene transfer agent.
Solubility
Soluble in acetonitrile, ether and dichloromethane. Insoluble in water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature: 2 - 8°C. Incompatible with strong oxidizing agents.
Specifications
Specifications
| Density | 1.16 |
| Boiling Point | 104°C to 105°C |
| Flash Point | 17°C (62°F) |
| Odor | Stench |
| Refractive Index | 1.498 |
| Quantity | 10 g |
| UN Number | UN1993 |
| Beilstein | 1730851 |
| Sensitivity | Moisture sensitive |
| Solubility Information | Soluble in acetonitrile,ether and dichloromethane. Insoluble in water. |
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Safety and Handling
- Chloromethyl methyl sulfide
- Danger
- Serious eye damage/eye irritation Category 2
- Flammable liquid Category 2
- Skin corrosion/irritation Category 2
- Specific target organ toxicity Category 3
- H225-Highly flammable liquid and vapour.
- H315-Causes skin irritation.
- H319-Causes serious eye irritation.
- H335-May cause respiratory irritation.
- P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- P264-Wash face, hands and anyexposed skin thoroughly after handling.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P312-Call a POISON CENTER/doctor/if you feel unwell.
- P332+P313-If skin irritation occurs: Get medical advice/attention.
- P337+P313-If eye irritation persists: Get medical advice/attention.
- MIXTURE LIST-Contains : Chloromethyl methylsulfide
RUO – Research Use Only