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Crizotinib, Tocris Bioscience™

Artikelnummer. 18025362
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Quantity:
10 mg
50 mg
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Beschreibung

Potent c-MET/ALK inhibitor

Potent inhibitor of c-MET and anaplastic lymphoma kinase (ALK) (cell IC50 values are 8.0 and 20 nM respectively). Selective for c-MET and ALK against >120 different kinases. Displays antitumor efficacy in multiple tumor models; inhibits c-MET-dependent proliferation, migration and invasion of human tumor cells in vitro. Orally bioavailable.

Chemische Identifikatoren

CAS 877399-52-5
Molecular Formula C21H22Cl2FN5O
Molecular Weight (g/mol) 450.34
MDL Number MFCD12407409
InChI Key KTEIFNKAUNYNJU-UHFFFAOYNA-N
Synonym crizotinib, xalkori, r-crizotinib, crizotinibum, 3-1r-1-2,6-dichloro-3-fluorophenyl ethoxy-5-1-4-piperidinyl-1h-pyrazol-4-yl-2-pyridinamine, xalkori tn, r-3-1-2,6-dichloro-3-fluorophenyl ethoxy-5-1-piperidin-4-yl-1h-pyrazol-4-yl pyridin-2-amine, crizotinib pf-02341066, 3-1r-1-2,6-dichloro-3-fluorophenyl ethoxy-5-1-piperidin-4-yl-1h-pyrazol-4-yl pyridin-2-amine, crizotinib pf-2341066
PubChem CID 11626560
ChEBI CHEBI:64310
IUPAC Name 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine
SMILES CC(OC1=C(N)N=CC(=C1)C1=CN(N=C1)C1CCNCC1)C1=C(Cl)C=CC(F)=C1Cl

Spezifikation

Assay Percent Range >99%
Quantity 10 mg
Formula Weight 450.34
Chemical Name or Material Crizotinib
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