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CYP1B1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA528040
This item is not returnable.
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Description
Recommended positive controls: 293T, mouse lung. Predicted reactivity: Mouse (84%), Rat (84%), Dog (82%), Rhesus Monkey (94%), Bovine (82%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
CYP1B1 is a 543 amino acid intracellular protein localized to the endoplasmic reticulum. It belongs to the cytochrome P450 super family of enzymes which are monooxygenases and it catalyzes many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol and is also involved in the metabolism of substances active in the eye growth and differentiation and hence plays a putative role in ocular development. Mutated proteins are known to cause primary congenital glaucoma.
Specifications
| CYP1B1 | |
| Polyclonal | |
| Unconjugated | |
| Cyp1b1 | |
| aryl hydrocarbon hydroxylase; benz[a]anthracene inducible; CP1B; CYP1B; CYP1B1; Cyp1-b1; CYPIB1; cytochrome P450 1B; cytochrome P450 1B1; cytochrome P450 family 1 subfamily B member 1; cytochrome P450, 1b1, benz[a]anthracene inducible; cytochrome P450, family 1, subfamily B, polypeptide 1; cytochrome P450, subfamily 1B, polypeptide 1; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile); cytochrome P4501B; cytochrome P450CMEF; Cytochrome P450EF; cytochrome P450RAP; flavoprotein-linked monooxygenase; GLC3A; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P4501B1; P450RAP; xenobiotic monooxygenase; zgc:136223 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 13078, 1545 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry, Western Blot | |
| 0.63 mg/mL | |
| PBS with 20% glycerol and 0.025% ProClin 300, pH 7 | |
| Q16678, Q64429 | |
| Cyp1b1 | |
| Recombinant fragment corresponding to a region within amino acids 224 and 492 of Human Cytochrome P450 1B1 | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |