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DDX58 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

1656.73 SEK - 4721.67 SEK

Specifications

Antigen DDX58
Concentration 0.51 mg/mL
Applications Western Blot, Immunoprecipitation, Immunofluorescence, Immunocytochemistry
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16830125
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Proteintech
20566-1-AP-20UL
20 μL
1656.73 SEK
20µL
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16820125
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Proteintech
20566-1-AP-150UL
150 μL
4721.67 SEK
150µL
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Description

Description

The antibody is specific to DDX58.

Retinoic acid-inducible gene I, RIG-I is a pattern recognition receptor (PRR) involved in the recognition of viral dsRNA. Along with MDA5, RIG-I detects viral dsRNA and activates the innate immune response. Both MDA5 and RIG-I are RNA helicases and they perform overlapping as well as distinct roles. RIG-I is activated by dsRNAs without a 5′-triphosphate end and short dsRNAs, whereas MDA5 is activated by long dsRNAs. Once activated, both proteins signal through IPS-1 activating transcription factors NF-kappaB and IRF-3 (1) and ultimately activating apoptosis, cytokine signaling, and inflammation. RIG-I is essential for signaling by influenza A, influenza B, human respiratory syncytial virus (3), paromyxoviruses, Japanese encephalitis virus, and West Nile virus. MicroRNA-146a has been implicated in feedback inhibition of RIG-I-dependant antiviral response by negatively regulating RIG-I targets TRAF6, IRAK1, and IRAK2. Recent evidence has implicated RIG-I in the detection of cytosolic DNA through RNA polymerase III activity.
Specifications

Specifications

DDX58
Western Blot, Immunoprecipitation, Immunofluorescence, Immunocytochemistry
Unconjugated
Rabbit
Mouse, Human
O95786, Q6Q899
230073, 23586
Peptide
Primary
-20°C
DDX58
0.51 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
DDX58, DEAD box protein 58, RIG 1, RIG I, RIG-I
Ddx58
IgG
Antigen Affinity Chromatography
Antibody
Videos
SDS
Documents

Documents

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