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  6. Deoxycholic acid, sodium salt, 99%, extra pure, Thermo Scientific Chemicals

Deoxycholic acid, sodium salt, 99%, extra pure, Thermo Scientific Chemicals

Product Code. 10732451
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Quantity:
25 g
100 g
500 g
Packaging:
Glass bottle

Description

Deoxycholic acid, sodium salt, CAS # 302-95-4, also designed as sodium deoxycholate, is a biological anionic bile acid detergent that is especially useful for disrupting and dissociating protein interactions.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • The deoxycholic acid sodium salt is a bile acid choleretic and anionic detergent that allows the solubilization of fats for intestinal absorption
  • The compound is an intermediate in the production of corticosteroids
  • In animal models it has been shown that this compound can promote tyrosine phosphorylation of β-catenin and its translocation to the nucleus, promoting the activation of β-catenin signaling


Applications

  • Deoxycholic acid is mainly useful for the extraction of membrane receptors, other plasma membrane proteins, nuclei isolation, solubilization and isolation of fats, and some components of biological membranes (in an active state)
  • It has been used for chemical applications, mainly for the elution or regeneration of specific types of affinity columns. Furthermore, this compound can be used to prevent non-specific binding in affinity chromatography.
  • It has been applied in the preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins
  • Deoxycholic acid, sodium salt is also recommended for stripping endotoxins
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 302-95-4
Molecular Formula C24H39NaO4
Molecular Weight (g/mol) 414.56
MDL Number MFCD00064139
InChI Key FHHPUSMSKHSNKW-SMOYURAASA-M
Synonym sodium deoxycholate
PubChem CID 91810855
SMILES [Na+].[H][C@@]12CC[C@H]([C@H](C)CCC([O-])=O)[C@@]1(C)[C@@H](O)C[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@H](O)CC[C@]12C

Specifications

Color White to Cream
pH 7.5 to 10 (5% aq. soln.)
Loss on Drying 5% max. (2 g, 105°C, 4 hrs)
Infrared Spectrum Authentic
Assay Percent Range 99%
Packaging Glass bottle
Quantity 100 g
Beilstein 10, III, 1642
Merck Index 14, 2899
Specific Rotation +42° to +46° (20°C, 589nm) (c=2, water)
IUPAC Name sodium;(4R)-4-[(3R,5R,8R,10S,12S,13R,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
Formula Weight 414.58
Percent Purity 98.5 to 102% (on dry substance)
Grade Extra Pure
Physical Form Crystalline Powder
Chemical Name or Material Deoxycholic acid, sodium salt
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Safety and Handling

compliance-icons
Product Identifier
  • Deoxycholic acid, sodium salt
 Signal Word
  • Warning
 Hazard Category
  • Acute toxicity Category 4
  • Specific target organ toxicity Category 3
 Hazard Statement
  • H335-May cause respiratory irritation.
  • H302-Harmful if swallowed.
 Precautionary Statement
  • P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P264-Wash thoroughly after handling.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P312-Call a POISON CENTER/doctor/if you feel unwell.

RUO – Research Use Only

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