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Endostatin Polyclonal Antibody, Biotin, PeproTech®, Invitrogen™

Rabbit Polyclonal Antibody

2180.00 SEK - 37440.00 SEK

Specifications

Antigen Endostatin
Concentration 0.1-1.0 mg/mL
Applications ELISA, Western Blot
Classification Polyclonal
Conjugate Biotin
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Products 4
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
17855773
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Invitrogen
500-P262BT-25UG
25 μg
2180.00 SEK
25µg
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17845163
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Invitrogen
500-P262BT-50UG
50 μg
2795.00 SEK
50µg
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17895273
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Invitrogen
500-P262BT-1MG
2 x 500 μg This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.
N/A
30054403
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Invitrogen
500-P262BT-500UG
500μg
19360.00 SEK
500µg
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Description

Description

AA Sequence of recombinant protein: MHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM TASK. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human Endostatin. Anti-Human Endostatin-specific antibody was purified by affinity chromatography and then biotinylated. Sandwich ELISA: To detect hEndostatin by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.25-1.0 μg/mL of this antibody is required. This biotinylated polyclonal antibody, in conjunction with PeproTech Polyclonal Anti-Human Endostatin (500-P262) as a capture antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant hEndostatin. Western Blot: To detect hEndostatin by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant hEndostatin is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions. 500-P262BT-1MG will be provided as 2 x 500 μg

Endostatin is able to avoke non-uniform response for proliferation, cell mount and migration of entothelial cells, which different endostatin binding characteristic, leads to the assumption that endostatin effect is strongly dependent from endothelial cell type. Furthermore endostatin inhibits angiogenesis and tumor growth in vivo by inducing apoptosis in endothelial cells. The local delivery of endostatin seems to specifically affect tumor-associated microvessels by reduction of the vessel density, diameter and functionality. Tumor cell migration and invasion was greatly reduced in the endostatin treated animals. Endostatin is non-toxic and does not induce aquired drug resistance and has therefor become a potent new therapy strategy in solid neoplasias. This therapy appears to have a high potential not only for the treatment of gliomas, the most common brain tumors, but also in other tumors. The ability of endostatin to inhibit neoangiogenesis is mediated, at least in part, by Zn^+2 binding and elastase processing. Widespread endostatin expression was found in elactic fibers in vessel walls and in some other basement membrane zones. Endostatin is released by neurons to accumulate in amyloid plaques in Alzheimer's disease.
Specifications

Specifications

Endostatin
ELISA, Western Blot
Biotin
Rabbit
Human
P39060
80781
E.coli-derived Recombinant Human Endostatin
Antigen affinity chromatography
COL18A1
0.1-1.0 mg/mL
Polyclonal
Lyophilized
RUO
PBS with no preservative
antiangiogenic agent; Col18a1; Collagen alpha-1(XVIII) chain; collagen type XVIII alpha 1 chain; collagen, type XVIII, alpha 1; endostatin; FLJ27325; FLJ34914; KNO; KNO1; KS; MGC74745; multi-functional protein MFP; NC1; Non-collagenous domain 1; procollagen, type XVIII, alpha 1
COL18A1
Primary
-20°C
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