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Estrogen Receptor alpha Monoclonal Antibody, Invitrogen™
Mouse Monoclonal Antibody
Brand: Invitrogen 491002
This item is not returnable.
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Description
Estrogen Receptors (ER) are members of the steroid family of nuclear receptors. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Each protein contains distinct functional domains required for transcriptional activation, binding to estrogen response elements (ERE) in DNA, constitutive dimerization, binding to heat shock proteins, and ligand recognition. ER is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to EREs. When bound to DNA, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are several different isoforms of both ER alpha and ER beta. ER is an important regulator of growth and differentiation in the mammary gland. The presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.
Estrogen Receptor alpha Monoclonal antibody specifically detects Estrogen Receptor alpha in Human samples. It is validated for ChIP Assay, Immunocytochemistry, Western Blot.
Specifications
| Estrogen Receptor alpha | |
| Monoclonal | |
| Unconjugated | |
| ESR1 | |
| DKFZp686N23123; ER; Er alpha; ER36; ERa; ERalpha; ER-alpha; ERalpha protein; ESR; esr 1; Esr1; esr-1; ESRA; Estr; Estra; Estradiol receptor; estrogen nuclear receptor alpha; Estrogen receptor; estrogen receptor 1; estrogen receptor 1 (alpha); estrogen receptor alpha; estrogen receptor alpha c-terminus splice variant 1-2; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; estrogen receptor alpha splice variant, CTERP-1; estrogen receptor alpha splice variant, ERalphaDup5; estrogen receptor alpha splice variant, ERalphai45a; estrogen receptor alpha splice variant, ERalphai45bL; estrogen receptor alpha splice variant, ERalphai45bS; estrogen receptor alpha splice variant, ERalphai45c; estrogen receptor alpha splice variant, ERalphai56; estrogen receptor alpha splice variant, ERalphai67; estrogen receptor alpha variant delta 4; estrogen receptor protein; estrogen receptor, alpha; ESTRR; hER-alpha36; I79_001166; Nr3a1; nuclear receptor; nuclear receptor subfamily 3 group A member 1; RNESTROR; RP1-130E4.1; unnamed protein product | |
| Mouse | |
| Ammonium sulfate precipitation | |
| RUO | |
| 2099 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ChIP Assay, Immunocytochemistry, Western Blot | |
| 2 mg/mL | |
| PBS with 0.01% thimerosal | |
| P03372 | |
| ESR1 | |
| NH2 terminus of the human estrogen receptor alpha using a peptide antigen (Q19-K32) conjugated to KLH | |
| 50 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG3 |