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  5. 18074992

Tocris Bioscience™ ET 18-OCH3

Selective PI-PLC inhibitor, also PAF receptor agonist

Brand:  Tocris Bioscience™ 7462/10

Product Code. 18074992

  • 1770.00 SEK / 10mg

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Description

Description

ET 18-OCH3 is a synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC50 = 9.6 μM in fibroblasts and adenocarcinoma cells). ET 18-OCH3 acts as an agonist at platelet-activating factor (PAF) receptors. ET 18-OCH3 is an antitumor lipid that selectively induces apoptosis in tumor cells, sparing normal cells, and activates the intracellular Fas/CD95 death receptor. ETH 18-OCH3 also triggers eryptosis and interacts with mitochondrial membranes to increase mitochondrial membrane permeability, leading to dysfunction and apoptosis. Racemic mixture.
Specifications

Specifications

4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium 4-oxide
10 mg
C27H58NO6P
70641-51-9
Phospholipase C Inhibitors
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