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STEMCELL Technologies FK506

Calcineurin/NFAT pathway inhibitor; Binds FKBP-12

2413.80 SEK - 9381.15 SEK

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Products 2

Product Code	Brand	Quantity	Price	Quantity & Availability
Product Code	Brand	Quantity	Price	Quantity & Availability
17180332 View Documents Promotion Details missing translation for 'viewProductCertificates'	STEMCELL Technologies 74152	10 mg	2413.80 SEK 10mg View alternative products Save Up to »	Estimated Shipment: 12-08-2024 Log in to see stock.	Please sign in to purchase this item. Need a web account? Register with us today!

17190332 View Documents Promotion Details missing translation for 'viewProductCertificates'	STEMCELL Technologies 74154	50 mg	9381.15 SEK 50mg View alternative products Save Up to »	Estimated Shipment: 28-08-2024 Log in to see stock.	Please sign in to purchase this item. Need a web account? Register with us today!

Description

FK506 is a macrolide antibiotic with potent immunosuppressive properties (Thomson et al.) It inhibits the calcineurin/NFAT pathway (Martinez-Martinez & Redondo) and binds with high affinity to FK506 binding protein 12 (FKBP-12) (Thomson et al.)
Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.)
In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.)
Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.)

Specifications

Description