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Tocris Bioscience™ FRAX 597, Tocris Bioscience™
Potent group I PAK inhibitor
Brand: Tocris Bioscience™ 6029/10
This item is not returnable.
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Description
FRAX 597 is a potent group I PAK inhibitor (IC50 values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). Exhibits significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms (IC50 >10 μM for PAK4). Inhibits proliferation of pancreatic cancer and schwannoma cells in vitro and exhibits antitumor effects in mice.Specifications
| FRAX 597 | |
| 6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one | |
| Soluble to 20mM in DMSO | |
| Yellow |
| 1286739-19-2 | |
| 10 mg | |
| Solid | |
| Bioactive Small Molecule |
For Research Use Only.