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Thermo Scientific™ GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK 293T Cells

GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T cells contain the human Endothelial Differentiation Receptor 3 (EDG3) stably integrated into the GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T cell line.

Brand:  Thermo Scientific™ K1713

Product Code. 10308723

  • 144600.00 SEK / Each
Estimated Shipment: 14-01-2025
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For Research Use Only. All usage must comply with product instructions.

This item is not returnable. View return policy

Description

Description

GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T cells contain the human Endothelial Differentiation Receptor 3 (EDG3) stably integrated into the GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T cell line. GeneBLAzer™ Gα15-NFAT-bla HEK293T cells (Cat. No. K1539) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element and the Promiscuous G protein, Gα15.

The GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T cells are functionally validated for Z' and EC50 concentrations of S1P. In addition, GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

EDG-3/S1P-3(Sphingosine-1-Phosphate-3) is a Gq/Gi/Go/Gα13/Gα12 coupled GPCR. EDG-3 has been shown to be responsible for bradycardia that has been induced in clinical trials as a side effect of the immunosuppressive drug FTY720 that targets EDG-1. EDG-3 has also been shown to induce vasodilation in response to sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF). The EDG-3 Receptor has also been shown to play a cooperative or redundant role in angiogenesis with EDG-1.

For Academic pricing please login or contact us at discoverysciences@invitrogen.com.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

NM_005226.2
Dividing Cells
Fluorescence
EDG3
Single Cell Clone Origin
2 x 106 Cells
EDG3
293T (HEK)
GPCR
Cell-based beta lactamase reporter gene
LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol.

Includes:
• GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T cells
• GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T Assay Protocol
• Certificate of Analysis

The GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.
FRET
EDG3-Galpha15-NFAT-bla HEK293T cells, EDG3-Galpha15-NFAT-bla HEK293TAssay Protocol, Certificate of Analysis
GeneBLAzer™
BLA (Beta-Lactamase)
Dividing Cells
GeneBLAzer™
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For Research Use Only. Not for use in diagnostic procedures.