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Invitrogen™ GeneBLAzer™ MC1R-CRE-bla CHO-K1 Cells
GeneBLAzer™ MC1R-CRE-bla CHO-K1 Cells
Brand: Invitrogen™ K1724
Additional Details : Weight : 0.01000kg
Description
GeneBLAzer™ MC1R CRE-bla CHO-K1 cells contain the human Melanocortin Receptor 1 (MC1R) stably integrated into the CellSensor™ CRE-bla CHO-K1 cell line. CellSensor™ CRE-bla CHO-K1 cells (Cat. no. K1535) contain a beta-lactamase reporter gene under control of the Cyclic AMP Response Element (CRE) response element.The GeneBLAzer™ MC1R CRE-bla CHO-K1 cells are functionally validated for Z' and EC50 concentrations of NDP-α-MSH. In addition, GeneBLAzer™ MC1R CRE-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
The MC1 receptor (previously refered to as MSH-R) is the melanocyte-stimulating hormone receptor expressed in melanocytes and involved in the regulation of pigment production. Two types of melanin exist: pheomelanin and eumelanin. Loss in function mutations in MC1R are associated with increased pheomelanin production, leading to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. MC1R is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles for MC1R have been identified correlating to skin and hair color, providing evidence that MC1R is an important component in determining normal human pigment variation. Additionally, the involvement of the melanocortins in inflammation and exocrine secretion are likely to spur the development of selective MC1 and MC5 compounds
For Academic pricing please login or contact us at discoverysciences@invitrogen.com.
Specifications
Liquid Nitrogen | |
Fluorescence | |
GeneBLAzer™ MC1R CRE-bla CHO-K1 cells (LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol). Includes: GeneBLAzer™ MC1R CRE-bla CHO-K1 cells, GeneBLAzer™ MC1R CRE-bla CHO-K1 Assay Protocol, Certificate of Analysis | |
CHO-K1 |
GeneBLAzer™ MC1R-CRE-bla CHO-K1 Cells, 2 x 106 Cells, ∽2,000,000 cells/vial at 2,000,000 cells/mL Quantity of Cells, CHO-K1 Cell Line, Fluorescent Detection Method, GPCRs Druggable Target, BLA (Beta-Lactamase) Reporter, Liquid Nitrogen Storage | |
Pharma and biopharma, drug discovery and development, target and lead identification and validation, G-protein coupled receptor biology, cell-based GPCR reporter assays | |
2 x 106 Cells | |
CHO-K1 Cells |
For Research Use Only. Not for use in diagnostic procedures.