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Glycyl-H 1152 dihydrochloride, Tocris Bioscience™

Product Code. 18054202
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Quantity:
1 mg
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Description

Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)

Glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride (Cat. No. 2414) that displays improved ROCKII selectivity. IC50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.

Specifications

CAS 913844-45-8
Molecular Formula C18H26Cl2N4O3S
Quantity 1 mg
Synonym rho kinase inhibitor iv, h-1152 glycyl dihydrochloride
InChI Key ILDBNQGLZFSHQZ-FMOMHUKBSA-N
SMILES CC1CN(CCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)C)C(=O)CN.Cl.Cl
IUPAC Name 2-amino-1-[(3R)-3-methyl-4-(4-methylisoquinolin-5-yl)sulfonyl-1,4-diazepan-1-yl]ethanone;dihydrochloride
Molecular Weight (g/mol) 449.391
PubChem CID 71433876
Formula Weight 449.4
Percent Purity >99%
Chemical Name or Material Glycyl-H 1152 dihydrochloride
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