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GPLD1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA552941
This item is not returnable.
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Description
Immunogen sequence: FWSTNIYHLT SFMLENGTSD CNLPENPLFI ACGGQQNHTQ GSKMQKNDFH RNLTTSLTES VDRNINYTER GVFFSVNSWT PDSMSFIYKA LERNIRTMFI GGSQLSQKHV SS Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 68%.
GPLD1 is expressed in numerous tissues and cells and specifically cleaves GPI-anchored proteins. Liver has the highest level of GPI-PLD expression and is the primary organ contributing to GPLD1 in the serum. GPLD1 is abundant in serum in which it associates with polipoproteins AI and AIV. Increased serum GPLD1 is associated with insulin resistance and elevated serum triglycerides. Many surface proteins are attached to eukaryotic cell membranes via glycosylphosphatidylinositol (GPI) anchors that are covalently bound to the C-terminus of the protein and cleavage of the GPI moiety by GPLD1, only enzyme known that cleavage GPI anchor, may represent a means of regulating attachment of these proteins to the cell surface, or alternatively, their release into the extracellular environment.Specifications
GPLD1 | |
Polyclonal | |
Unconjugated | |
GPLD1 | |
6330541J12Rik; AW546131; glycoprotein phospholipase D; glycosylphosphatidylinositol phospholipase D; glycosylphosphatidylinositol specific phospholipase D1; glycosylphosphatidylinositol specific phospholipase D1, isoform 2; Glycosyl-phosphatidylinositol-specific phospholipase D; GPIPLD; GPI-PLD; GPIPLDM; GPI-specific phospholipase D; Gpld1; MGC22590; Phosphatidylinositol-glycan-specific phospholipase D; PI-G PLD; PIGPLD; PIGPLD1; PLD | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
2822 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry | |
0.05 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
P80108 | |
GPLD1 | |
Recombinant protein corresponding to Human GPLD1 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only