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GSK 2193874
Potent and selective TRPV4 antagonist; orally active
Brand: Tocris Bioscience 5106/25
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Description
GSK 2193874 is a potent and selective TRPV4 antagonist (IC50 values are 2 and 40 nM for rat and human receptors, respectively); inhibits Ca2+ influx through TRPV4 channels. Prevents and reverses pulmonary edema after myocardial infarction in vivo models. Selective over a panel of ∽200 human receptors, channels and enzymes. Orally active.Specifications
| 3-([1,4'-Bipiperidin]-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide | |
| >98% | |
| C37H38BrF3N4O |
| 1336960-13-4 | |
| 25 mg | |
| Observed MW: 691.62 |