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HRI Recombinant Polyclonal Antibody (7HCLC), Invitrogen™
Rabbit Recombinant Polyclonal Antibody
Brand: Invitrogen 711581
Description
This antibody is predicted to react with Monkey, Horse, Mouse Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
EIF2AK1 (HRI) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK1, signaling is initiated by low levels of heme. The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands and kinase activity is induced by low levels of heme and inhibited by the presence of heme.Specifications
HRI | |
Recombinant Polyclonal | |
0.5 mg/mL | |
PBS with 0.09% sodium azide; pH 7.4 | |
Q9BQI3 | |
EIF2AK1 | |
Protein corresponding to human HRI regulated inhibitor(HRI) (aa271-630) | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG |
Immunoprecipitation, Western Blot | |
7HCLC | |
Unconjugated | |
EIF2AK1 | |
EIF2AK1; eukaryotic translation initiation factor 2 alpha kinase 1; eukaryotic translation initiation factor 2-alpha kinase 1; HCR; he; heme regulated initiation factor 2 alpha kinase; heme sensitive initiation factor 2a kinase; heme-controlled repressor; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; heme-regulated inhibitor; heme-regulated initiation factor 2-alpha kinase; heme-regulated repressor; hemin-sensitive initiation factor 2a kinase; hemin-sensitive initiation factor 2-alpha kinase; Hri; KIAA1369; PRO1362 | |
Rabbit | |
Protein A | |
RUO | |
27102 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |