Recombinant Protein
Brand: Gibco™ PHG0261
7486.00 SEK valid until 2025-05-31
Use promo code "25977" to get your promotional price.
Carrier-Free Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile, distilled water to a concentration of 0.1-0.5 mg/mL. Apportion the reconstituted protein into working aliquots and store at ≤-20°C. Make any further dilutions of the reconstituted protein in medium, or buffered solution containing carrier protein (e.g., PBS with 0.1% BSA). Storage: Store the lyophilized protein at 2-8°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at ≤-20°C (not in a frost-free freezer). Avoid repeated freeze-thaw cycles.
FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.
| P09038 | |
| protein with no preservative | |
| 17.2 kDa | |
| Sequential Chromatography | |
| <0.1 ng/ μg | |
| FGF2 | |
| Unconjugated | |
| Recombinant | |
| 4°C | |
| Approved for shipment on Wet or Dry Ice | |
| Growth Factors & Receptors | |
| Lyophilized | |
| Neurobiology, Oncology, Stem Cell Research, Microbiology, Differentiation, Angiogenesis | |
| >95% by SDS-PAGE |
| Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot | |
| 2247 | |
| Human FGF-basic (FGF-2/bFGF) (aa 1-155) | |
| 100 μg | |
| Basic fibroblast growth factor; basic fibroblast growth factor bFGF; bFGF; FGF; fgf basic; Fgf2; Fgf-2; Fgfb; FGF-b; Fibroblast growth factor; fibroblast growth factor 2; fibroblast growth factor 2 (basic); HBGF-2; Heparin-binding growth factor 2; H-FGF-b-147; H-FGF-b-154; M-FGF-b; Prostatic growth factor; prostatropin | |
| ED50 = 0.1 - 1.0 ng/mL; determined by the dose-dependent proliferation of BALB/3T3 cells. | |
| Human | |
| Human FGF-basic, amino acids Met134-Ser288 with C211S and C229S substitutions and an N-terminal Gly-His | |
| <0.1 ng/μg | |
| E. coli | |
| Recombinant, Ligand | |
| FGFs (Fibroblast Growth Factors) | |
| Gibco™ |
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A lot number is required to show results for certificates. To find your lot number on previous orders use our order status area.
| Lot Number | Certificate Type | Date | Catalog Number |
|---|---|---|---|
| 3055415 | Certificate of Analysis | 31/01/2025 | PHG0261 |
| 2874965 | Certificate of Analysis | 26/01/2025 | PHG0261 |
| 2986793 | Certificate of Analysis | 25/01/2025 | PHG0261 |
| 1611169A | Certificate of Analysis | 16/04/2017 | PHG0261 |
| 1676534B | Certificate of Analysis | 15/04/2017 | PHG0261 |
Expires: 2025-05-31
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