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Gibco™ Human GDNF Recombinant Protein

Recombinant Protein

Brand: Gibco™ PHC7043

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Product Code. 10737683

68500.00 SEK / Each

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For Research Use Only. All usage must comply with product instructions.

This item is not returnable. View return policy

Description

Carrier-Free Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute lyophilized human GDNF in sterile, distilled water to 0.1-0.5 mg/mL. These stock solutions should be apportioned into working aliquots and stored at ≤-20°C. Further dilution should be made in medium or buffered solution containing carrier protein, such as PBS with 0.1% BSA. Storage: Lyophilized human GDNF should be stored at 2°C to 8°C, preferably desiccated. Store reconstituted human GDNF at ≤-20°C (not in a frost-free freezer). Keep freeze-thaw cycles to a minimum.

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.

Specifications

Accession Number	P39905
Formulation	protein with no preservative
Molecular Weight (g/mol)	30.1 kDa
Purification Method	Sequential Chromatography
Endotoxin Concentration	<0.1 ng/ μg
Common Name	GDNF
Conjugate	Unconjugated
Recombinant	Recombinant
Content And Storage	4°C
Endotoxin Level	<0.1 ng/μg
Expression System	E. coli
Protein Form	Recombinant, Ligand
Protein Subtype	Neurotrophic Factors
Product Line	Gibco™

For Use With (Application)	Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot
Gene ID (Entrez)	2668
Name	Human GDNF
Quantity	1 mg
Gene Alias	AI385739; Astrocyte-derived trophic factor; ATF; ATF1; ATF2; Gdnf; glial cell derived neurotrophic factor; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; glial cell line-derived neurotrophic factor; gndf; HFB1-GDNF; hGDNF; H-GDNF; HSCR3; mGDNF; neurotrophic factor
Biological Activity	ED50 ≤ 10 n/mL; determined by the dose-dependent neurite outgrowth of PC-12 cells in the presence of soluble GFR-alpha.
Species	Human
Sequence	SPDKQMAVLP RRERNRQAAA ANPENSRGKG RRGQRGKNRG CVLTAIHLNV TDLGLGYETK EELIFRYCSG SCDAAETTYD KILKNLSRNR RLVSDKVGQA CCRPIAFDDD LSFLDDNLVY HILRKHSAKR CGCI
Classification	Carrier-Free
Shipping Condition	Approved for shipment on Wet or Dry Ice
Protein Family	Growth Factors & Receptors
Form	Lyophilized
Research Category	Neurobiology, Stem Cell Research, Differentiation
Purity or Quality Grade	>98% by SDS-PAGE

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Gibco™ Human GDNF Recombinant Protein

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