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Gibco™ Human VEGF-121 Recombinant Protein, PeproTech®
E. coli Recombinant Protein
814.00 SEK - 39660.00 SEK
Specifications
Accession Number | P15692 |
---|---|
For Use With (Application) | Functional Assay |
Formulation | protein with no preservative |
Gene ID (Entrez) | 7422 |
Molecular Weight (g/mol) | 28.4 |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17841363
|
Gibco™
100-20A-100UG |
100 μg |
7930.00 SEK
100µg |
Estimated Shipment: 16-09-2024 Log in to see stock. |
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17820573
|
Gibco™
100-20A-10UG |
10 μg |
2005.00 SEK
10µg |
In Stock Log in to see stock. |
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17860783
|
Gibco™
100-20A-1MG |
1 mg |
39660.00 SEK
1mg |
Estimated Shipment: 16-09-2024 Log in to see stock. |
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17820123
|
Gibco™
100-20A-250UG |
250 μg |
13910.00 SEK
250µg |
Estimated Shipment: 16-09-2024 Log in to see stock. |
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17840673
|
Gibco™
100-20A-2UG |
2 μg |
814.00 SEK
2µg |
Estimated Shipment: 16-09-2024 Log in to see stock. |
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17870013
|
Gibco™
100-20A-500UG |
500 μg |
23830.00 SEK
500µg |
Estimated Shipment: 16-09-2024 Log in to see stock. |
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17820473
|
Gibco™
100-20A-50UG |
50 μg |
4750.00 SEK
50µg |
Estimated Shipment: 16-09-2024 Log in to see stock. |
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Description
VEGF (vascular endothelial growth factor) which is a 45 kDa homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. VEGF has a variety of effects on vascular endothelium, including the ability to promote endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability. The VEGF family currently includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PIGF. VEGF and its receptor system have been shown to be the fundamental regulators in the cell signaling of angiogenesis. Most tumors have the absolute requirement of angiogenesis, and VEGF has been described as the most potent angiogenic cytokine linked to this process. To date 5 different isoforms of VEGF have been described. These isoforms are generated as the result of alternative splicing from a single VEGF gene. These various isoforms have been shown to bind to two tyrosine-kinase receptors flt-1 (VEGFR-1) and flk-1/KDR (VEGFR-2), which have been found to be expressed almost exclusively on endothelial cells. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. Studies have shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis. Elevated levels of VEGF is linked to POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes) also known as Crow-Fukase syndrome which affects multiple organs in the body.Specifications
P15692 | |
protein with no preservative | |
28.4 | |
E. coli | |
RUO | |
angiogenic factor; etID309976.16; eVEGF120; eVEGF164; human VEGF121 homolog; MGC70609; MVCD1; ovine vascular endothelial growth factor; RP1-261G23.1; unnamed protein product; VAS; vascular endothelial growth factor; vascular endothelial growth factor (VEGF) precursor; vascular endothelial growth factor 121 isoform; vascular endothelial growth factor 164; vascular endothelial growth factor 165 b; vascular endothelial growth factor 182; vascular endothelial growth factor 182 isoform; vascular endothelial growth factor 188; vascular endothelial growth factor 188 isoform; vascular endothelial growth factor 189; vascular endothelial growth factor A; vascular endothelial growth factor A121; vascular endothelial growth factor A165; vascular endothelial growth factor Aa; Vascular endothelial growth factor A-A; vascular endothelial growth factor isoform 165; vascular permeability factor; Vasculotropin; VEGF; VEGF1; VEGF164; VEGF182; VEGF188; vegfa; VEGF-A; VEGFA165b; vegfaa; VEGF-A-A; VEGFMGC70 | |
Human | |
Recombinant | |
Lyophilized |
Functional Assay | |
7422 | |
Human VEGF-121 | |
-20°C | |
<1 EU/μg | |
VEGFA | |
Unconjugated | |
APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENCDKPR R | |
≥ 98% by SDS-PAGE gel and HPLC analyses. |