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Eurofins DiscoverX IGF-1R Protein, Activated
Activated on column by incubating with Mg/ATP, excess ATP and MgAc removed by multiple column wash steps.
Brand: Eurofins DiscoverX 14-802M
This item is not returnable.
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Description
Insulin-like growth factor (IGF) binding to the IGF receptors initiates an intracellular signaling cascade that leads to changes in gene expression and cell biology. Although multiple receptors for the IGFs have been identified, the IGFs primarily exert their biologic effects through ligation of the IGF1R (type I IGF receptor tyrosine kinase, JTK13). IGF1R exerts mitogenic, cell survival, and insulin-like activities, is involved in postnatal growth physiology, and is connected to proliferative disorders such as breast cancer.
GenBank X04434
Specifications
| mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol, 5 mM β-glycerophosphate, 1 mM Na3VO4. Frozen solution. | |
| 250 μg | |
| Recombinant | |
| Recombinant enzyme expressed in Sf21 insect cells | |
| ≥73% |
| 48 kDa | |
| Human | |
| N-terminal 6His | |
| Truncated | |
| IGF-1R, activated |
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