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Tocris Bioscience™ Imipramine hydrochloride

Potent inhibitor of 5-HT and noradrenalin transporters; promotes immunostimulatory tumor microenvironment

Brand:  Tocris Bioscience™ 7841/50

Product Code. 18727176

  • 1020.00 SEK / 50mg

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Description

Description

Imipramine hydrochloride is a potent tricyclic antidepressant; inhibits 5-HT and noradrenalin transporters (Ki values = 1.3-20 nM and 20-142 nM respectively). Increases autophagy, both alone and in combination with VEGF inhibitors or Temozolomide (Cat. No. 2706), to reduce the progression of glioma and slow the proliferation of other tumors. Reprograms tumor-associated macrophages from immunosuppressive to immunostimulatory via histamine receptor inhibition.
Specifications

Specifications

5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride
50 mg
C19H24N2.HCl
113-52-0
Autophagy-related Compounds
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