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Tocris Bioscience™ IRAK3 Degrader 23
IRAK3 PROTAC™ Degrader
Brand: Tocris Bioscience™ 7983/5
3377.02 SEK valid until 2024-12-16
Use promo code "21630" to get your promotional price.
This item is not returnable.
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Description
IRAK3 Degrader 23 is a potent and selective IRAK3 PROTAC™ Degrader (DC50 = 2 nM; Dmax = 98% in THP1 cells and primary macrophages), requires CRBN and IRAK3 binding for Degrader activity. Also inhibits CDK11, CDK8, TRKC and GSG2 (IC50 values are 16 nM, 36 nM, 100 nM and 110 nM respectively).PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.Specifications
| 2-(2,6-Dioxo-3-piperidyl)-5-[4-[2-[1-[4-[4-[cis-4-[(5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]cyclohexyl]-piperazin-1-yl]-4-oxo-butanoyl]-4-piperidyl]ethyl]piperazin-1-yl]-isoindoline-1,3-dione | |
| 5 mg | |
| C47H63N11O6 |
| 2712600-00-3 | |
| Active Degraders | |
| 0.98 |