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Eurofins DiscoverX IRAK4 Protein, Active

Active, N-terminal His6-tagged, recombinant full length, human IRAK4, for use in Kinase Assays.

Encompass_Preferred

6046.30 SEK - 46147.75 SEK

Specifications

Formulation mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Molecular Weight (g/mol) 55.4 kDa
Species Human
Recombinant Recombinant
Protein Tag N-terminal 6His
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Product Code Brand Quantity Price Quantity & Availability  
17340404
Encompass_Preferred
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Eurofins DiscoverX
14-599 		10 μg
6046.30 SEK
10µg
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17350404
Encompass_Preferred
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Eurofins DiscoverX
14-599M 		250 μg
46147.75 SEK
250µg
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Description

Description

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.

GenBank AF445802

Specifications

Specifications

mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Human
N-terminal 6His
Full-length
IRAK4, active
55.4 kDa
Recombinant
Recombinant enzyme expressed in Sf21 insect cells
≥64%
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