missing translation for 'onlineSavingsMsg'
Learn More

STEMCELL Technologies IWR-1-endo

WNT pathway inhibitor; AXIN2 stabilizer

1359.45 SEK - 5356.80 SEK

View More Specs

Products 2

Product Code	Brand	Quantity	Price	Quantity & Availability
Product Code	Brand	Quantity	Price	Quantity & Availability
17100092 View Documents Promotion Details missing translation for 'viewProductCertificates'	STEMCELL Technologies 72562	5 mg	1359.45 SEK 5mg View alternative products Save Up to »		Please sign in to purchase this item. Need a web account? Register with us today!

17110092 View Documents Promotion Details missing translation for 'viewProductCertificates'	STEMCELL Technologies 72564	25 mg	5356.80 SEK 25mg View alternative products Save Up to »		Please sign in to purchase this item. Need a web account? Register with us today!

Description

IWR-1-endo potently inhibits WNT signaling by blocking a cell-based WNT/β-catenin pathway reporter response with an IC₅₀ value of 180 nM (Chen et al.) It inhibits WNT-induced accumulation of β-catenin, through stabilization of the destruction complex member AXIN2 (Chen et al.)
Promotes self-renewal and maintains pluripotency of human embryonic stem cells and mouse Epi-stem cells when used in combination with CHIR99021 (Kim et al.) DIFFERENTIATION
Promotes differentiation of cardiomyocytes from human pluripotent stem cells (PSCs) that have been induced to mesoderm by addition of Activin A and/or BMP4 (Ren et al.; Willems et al.)
Induces the differentiation of human PSC-derived alveolar epithelial type II (AETII) to AETI cells (Ghaedi et al.)

Specifications

Description