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Jasplakinolide, Tocris Bioscience™

Product Code. 30001470
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Quantity:
100 μg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Stabilizes F-actin; promotes actin polymerization

Rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro. Also induces polymerization of actin monomers into F-actin in vivo. Shown to bind to F-actin competitively with phalloidin (Cat. No. 4535) (Kd ∽ 15 nM). Exhibits antifungal and antiproliferative effects (IC50 = 35 nM for antiproliferative activity in PC3 cells). Cell permeable.

Specifications

CAS 102396-24-7
Molecular Formula C36H45BrN4O6
Quantity 100 μg
Synonym jasplakinolide
InChI Key GQWYWHOHRVVHAP-JFKHFEEVSA-N
SMILES CC1CC(OC(=O)CC(NC(=O)C(N(C(=O)C(NC(=O)C(CC(=C1)C)C)C)C)CC2=C(NC3=CC=CC=C32)Br)C4=CC=C(C=C4)O)C
IUPAC Name (4R,7R,10S,13S,15E,17R,19R)-7-[(2-bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone
Molecular Weight (g/mol) 709.682
PubChem CID 131843168
Formula Weight 709.67
Percent Purity >97%
Chemical Name or Material Jasplakinolide
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