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Kifunensine, Tocris Bioscience™

Product Code. 18064762
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Quantity:
1 mg
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Description

Inhibitor of class I α-mannosidases

Kifunensine is an inhibitor of class I α-mannosidases that inhibits glycoprotein processing. Kifunensine inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively. Kifunensine disrupts normal trafficking of the GLUT1 transporter, leading to decreased glucose uptake in human renal epithelial cells. Kifunensine impaires tumour cell aggregation in human ovarian cancer cells in vitro.

Specifications

CAS 109944-15-2
Molecular Formula C8H12N2O6
Quantity 1 mg
Synonym kifunensine, +-kifunensine, kifunensine, kitasatosporia kifunense, 5r,6r,7s,8r,8as-6,7,8-trihydroxy-5-hydroxymethyl hexahydroimidazo 1,2-a pyridine-2,3-dione, kif, 5r,6r,7s,8r,8as-6,7,8-trihydroxy-5-hydroxymethyl-1,5,6,7,8,8a-hexahydroimidazo 1,2-a pyridine-2,3-dione, 5r,6r,7s,8r,8as-hexahydro-6,7,8-trihydroxy-5-hydroxymethyl-imidazo 1,2-a pyridine-2,3-dione, imidazo 1,2-a pyridine-2,3-dione, hexahydro-6,7,8-trihydroxy-5-hydroxymethyl-, 5r-5alpha,6beta,7alpha,8alpha,8aalpha, 2wvz, d0ad9y
InChI Key OIURYJWYVIAOCW-PQMKYFCFSA-N
SMILES C(C1C(C(C(C2N1C(=O)C(=O)N2)O)O)O)O
IUPAC Name (5R,6R,7S,8R,8aS)-6,7,8-trihydroxy-5-(hydroxymethyl)-1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-2,3-dione
Molecular Weight (g/mol) 232.192
PubChem CID 130611
Formula Weight 232.19
Percent Purity >98%
Chemical Name or Material Kifunensine
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