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Tocris Bioscience™ LDN 193189 dihydrochloride

Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs

1575.00 SEK - 11640.00 SEK

Specifications

Chemical Name or Material	4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
CAS	1435934-00-1
Synonym	4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Target	BMP and Other Activin Receptor Inhibitors
Molecular Formula	C₂₅H₂₂N₆0.2 HCl

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Products 3

Product Code	Brand	Quantity	Price	Quantity & Availability
Product Code	Brand	Quantity	Price	Quantity & Availability
18707806 View Documents missing translation for 'viewProductCertificates'	Tocris Bioscience™ 6053/10	10 mg	3065.00 SEK 10mg		Please sign in to purchase this item. Need a web account? Register with us today!

18787766 View Documents missing translation for 'viewProductCertificates'	Tocris Bioscience™ 6053/50	50 mg	11640.00 SEK 50mg		Please sign in to purchase this item. Need a web account? Register with us today!

18075802 View Documents missing translation for 'viewProductCertificates'	Tocris Bioscience™ 6053/1	1 mg	1575.00 SEK 1mg		Please sign in to purchase this item. Need a web account? Register with us today!

Description

LDN 193189 dihydrochloride is a potent and selective ALK2 and ALK3 inhibitor (IC50 values are 5 and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation. Exhibits >200-fold selectivity for BMP signaling over TGF-β signaling. Also exhibits selectivity over AMPK, PDGFR and MAPK signaling. Promotes neural induction of hPSCs in combination with SB 431542 (Cat.No. 1614). Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat.No. 1614), SU 5402 (Cat.No.3300), CHIR 99021 (Cat.No. 4423) and DAPT (Cat.No. 2634).

LDN 193189 synthesized to Ancillary Material Grade also available.

For more information about how LDN 193189 dihydrochloride may be used, see our protocols: Generation of β cells from hPSCs, Generating Midbrain Dopaminergic Neurons from hPSCs, Accelerated Induction of Cortical Neurons from hiPSCs .

Specifications

Chemical Name or Material	4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Synonym	4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Molecular Formula	C₂₅H₂₂N₆0.2 HCl
Physical Form	Solid
Product Type	Bioactive Small Molecule

CAS	1435934-00-1
Target	BMP and Other Activin Receptor Inhibitors
Formula Weight	479.4
Color	Orange
Purity	98%

Safety and Handling

Recommended Storage : Store at -20°C

For Research Use Only.

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Tocris Bioscience™ LDN 193189 dihydrochloride

Specifications

Description

Specifications

Safety and Handling

Documents