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STEMCELL Technologies LDN193189 (Dihydrochloride)

BMP pathway inhibitor; Inhibits ALK1, ALK2, ALK3, and ALK6

Brand: STEMCELL Technologies 72147

Product Code. 17120032

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Description

LDN193189 is a potent inhibitor of the bone morphogenetic (BMP) pathway, inhibiting ALK1, ALK2, ALK3, and ALK6 (IC₅₀ = 0.8, 0.8, 5.3, and 16.7 nM respectively; Sanvitale et al.) It is a derivative of Dorsomorphin (Catalog #72102) that is typically used at approximately 100-fold lower concentrations (Sanvitale et al.; Vogt et al.) This product is supplied as the dihydrochloride salt of the molecule and it is the most soluble version of LDN193189
Promotes differentiation of neural progenitor cells from human pluripotent stem cells (Chambers et al.; Kriks et al.)
Promotes differentiation of neural crest cells from human pluripotent stem cells (Kreitzer et al.)
Promotes differentiation of anterior foregut endoderm from human and mouse pluripotent stem cell-derived definitive endoderm (Kearns et al.)
Promotes differentiation of sensory epithelial cells of the inner ear from mouse embryonic stem cells (Koehler et al.)
Inhibits prostate and breast cancer tumor growth (Balboni et al.; Lee et al.)
Prevents ovarian cancer cell proliferation (Tsai et al.)

Specifications

Synonym	DM-3189
Molecular Formula	C₂₅H₂₂N₆ · 2HCl

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