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LE 135, Tocris Bioscience™

Product Code. 18005972
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Selective RARβ antagonist

Retinoic acid antagonist; displays moderate selectivity for RARβ over RARα (Ki values are 0.22 and 1.4 μM respectively). Highly selective over RARγ and RXRα. Inhibits human HL-60 leukemia cell differentiation induced by Am80 (IC50 = 150 nM).

Chemical Identifiers

CAS 155877-83-1
Molecular Formula C29H30N2O2
InChI Key YZZAIQOVMHVWBS-UHFFFAOYSA-N
PubChem CID 10410894

Specifications

Quantity 10 mg
Synonym chembl37708, 4-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho 2,3-b 1, 4 benzodiazepin-13-yl benzoic acid, 4-5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5h-benzo e naphtho 2,3-b 1,4 diazepin-13-yl benzoic acid, d0x5wp, 4-7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-5h-benzo e naphtho 2,3-b 1,4 diazepin-13-yl benzoic acid, 4-5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5 h-5,12-diaza-benzo 4,5 cyclohepta 1,2-b naphthalen-13-yl-benzoic acid, 4-5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5 h-5,12-diaza-benzo 4,5 cyclohepta 1,2-b naphthalen-13-yl-benzoic acid
SMILES CN1C2=CC=CC=C2C(=NC2=C1C=C1C(=C2)C(C)(C)CCC1(C)C)C1=CC=C(C=C1)C(O)=O
IUPAC Name 4-{2,14,14,17,17-pentamethyl-2,10-diazatetracyclo[9.8.0.0³,⁸.0¹³,¹⁸]nonadeca-1(11),3,5,7,9,12,18-heptaen-9-yl}benzoic acid
Molecular Weight (g/mol) 438.57
Formula Weight 438.56
Percent Purity >97%
Chemical Name or Material LE 135
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